Bad Ends by Source
There are many transformation items and NPCs that a player can interact with in Trials in Tainted Space, but overindulgence and certain characters can transform, warp or otherwise alter a player in ways that mean they either can no longer physically undertake their quest, or that they no longer wish to undertake that quest. These are known as Bad Ends or Game Over.
This article lists the various Bad Ends that it is possible to experience in the game, how they can be achieved, and the basics of those Bad Ends.
Substance Abuse
This section covers all bad ends that results from using an item numerous times. Most of it involves the champion transforming into a monster/creature or addicting the player to the way the item makes them feel that they drop whatever they were doing in favor of feeling that way forever.